NEI in Orlando a Huge Success

The EnLyte team presented at the Neuroscience Education Institute meeting in Orlando November 11-15. Highlights included a poster presentation, Psychiatric Annals Guest Editor, Andrew Farah, MD, who was available to answer questions and review his recently published articles, and industry matinees presented to a “standing room only” crowd by leading expert, Dr. Lawrence Ginsberg. View the NEI Poster hereAccess Dr. Farah’s Psychiatric Annals publications here.


JayMac Pharmaceuticals Recognizes National Infertility Awareness Week: A Focus on Male Infertility, Homocysteine, & the Need for Folate Therapy

SUNSET, La., April 17, 2015 (GLOBE NEWSWIRE) — April 19th begins National Infertility Awareness Week, and JayMac Pharmaceuticals is shedding light on an often overlooked area: male infertility and the need for folate therapy.

Approximately 2 million men suffer from infertility. In fact, in developed countries, up to 70% of infertility experienced by couples trying to conceive can be attributed to male reproductive issues. Many studies have uncovered one such issue as the presence of the MTHFR gene abnormality being the source of what is termed idiopathic male infertility.

DNA, MTHFR, & Homocysteine

MTHFR (Methylenetetrahydrofolate Reductase) is the enzyme encoded for the metabolism of folate. Folate is a critical component of DNA methylation and synthesis. The presence of the MTHFR enzyme abnormality occurs in about 60% of the general population and can result in as much as a 70% reduction in the ability of the enzyme to metabolize folate to the necessary form to fuel the DNA methylation cycle. This impaired DNA methylation can cause abnormal male sexual development and reproductive performance.

A further consequence of impaired folate metabolism is the buildup of the amino acid homocysteine, as the metabolism of homocysteine is folate-dependent. Homocysteine is implicated in a wide array of health conditions including infertility and pregnancy complication and loss. Folate therapy in the form of diverse, unique, and brain-ready components is critical to the reduction of homocysteine and completion of the DNA remethylation cycle.

A recent study published in 2014 in Ege Journal of Medicine found a strong correlation between the presence of the MTHFR polymorphism and idiopathic male infertility: “DNA methylation is necessary for spermatogenesis. C677T polymorphism of the MTHFR gene increased the DNA hypomethylation and affects the differentiation of the germ cells. MTHFR C677T polymorphism reduced the enzymatic activity and increased the homocysteine levels. High levels of homocysteine can lead to auto-oxidation which can damage the germ line DNA and sperm plasma membrane.

About JayMac Pharmaceuticals

JayMac Pharmaceuticals, LLC, based in Sunset, Louisiana, is expanding its prescription folate product line to specifically address the needs of patients facing male and female infertility and high risk pregnancy due to genetic polymorphisms (MTHFR), high homocysteine, and low folate levels. The new folate product is projected to be available June 2015.

Makers of EnLyte Honor Autism Awareness Month

SUNSET, La., April 16, 2015 (GLOBE NEWSWIRE) — The rate of autism is now up to 1 in 68 children, according to the CDC. How does homocysteine have a significant impact on this population?

Homocysteine (HCY) is an amino acid that, when high, is implicated in numerous serious physical and mental health conditions.

High HCY results from faulty or impaired methylation, very commonly due to a gene sequence abnormality called MTHFR-found in about 60% of the US population, and in as much as 90% of those with autism. For those with the MTHFR defect, folic acid from diet or supplements is not metabolized to the active form the brain needs, L-Methylfolate. Reduction of HCY relies on a specific combination of vitamins and cofactors, which must be pre-metabolized to be effective in persons with the MTHFR defect.

Many ASD children present with low homocysteine levels. A growing body of literature underscores that under conditions of oxidative stress homocysteine is used to generate glutathione. Such conditions may obviate any increases in plasma homocysteine DESPITE FOLATE DEFICIENCY.
In autism, the impact of HCY begins at preconception and continues through the life span.

Prevention of Autism with Prenatal Care

We know that autism rates continue to rise. Why? Folic acid is fortified in our food and is in prenatal vitamins. What we know now is that because the MTHFR gene is so common, prenatal vitamins or a stellar diet fall may fall short in complete prevention. The folic acid will not be broken down to the active form used by the brain needed to prevent neurogenerative disorders such as autism. According to Dr. David Berger, MD, of Wholistic Pediatrics,”Because women who have the abnormal MTHFR gene sequence may not be able to efficiently complete the conversion of folic acid to methylfolate, they may have issues if taking only folic acid. In such cases, I recommend that women not take folic acid but rather L-methylfolate or folinic acid or possibly a combination of both. These two forms bypass the faulty MTHFR enzyme and provide the fetus with activated folate.”

Homocysteine In Persons With Autism

With MTHFR being present in as much as 90% of autism cases, high homocysteine is a big contributor to health issues and behavior. According to Lawrence Ginsberg, MD, Red Oak Psychiatry, factors like diet restrictions, absorption issues, and genetic factors-most notably the MTHFR defect-are unique and significant to autism, being major players in decreasing the body’s ability to absorb B vitamins. Dr. Ginsberg finds many parents welcome an alternative to antipsychotics in their children with autistic spectrum disorders. The right supplement, with all the brain-ready components that bypass the MTHFR gene abnormality, can have a positive impact on quality of life and help to manage some associated symptoms and behaviors. Click here to read Dr. Ginsberg’s full interview.

Depression in Autism

A new study found suicidal thoughts were found to be more common in a sampling of autistic children vs. non-autistic children. Prescription options to treat depression in children/adolescents are limited and come with suicide warnings. In addition, the MTHFR gene defect and high HCY are linked with depression and with a lower response rate to antidepressants in many cases.

EnLyte in the Prevention and Treatment of Autism

EnLyte is an FDA-regulated prescription folate therapy containing L-Methylfolate magnesium, folinic acid, folacin, brain-ready metabolites of B1, B2, B3, B6, B12, betaine, zinc, magnesium, vitamin C, and PS gold omega 3s. It is certified gluten free and artificial dye free. EnLyte bypasses MTHFR and addresses HCY and folate deficiency in one gelcap per day. EnLyte can be squeezed out and administered over food for easy dosing. To learn more, visit www.EnLyteRx.Com. Click here for a patient brochure or to arrange samples for licensed prescribers.

Angela Hall
eSYNCS | Advertising Agency