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The Oil Refinery Analogy
 

Imagine your body as a big oil refinery, working hard to turn raw materials into useful products. In this depiction, the raw materials are folates and other vitamins and minerals, which you get from foods like leafy greens, beans, and fortified cereals.

First, these nutrients enter your body, just like crude oil arriving at a refinery. Your digestive system starts breaking it down into a usable form, much like the refinery processes the oil. This breakdown is extremely important because those usable forms are required to become the fuel to operate the biochemical engine called methylation.

 

Note: Some individuals have a genetic marker called MTHFR polymorphism that does not allow for the efficient or effective metabolization of folate that creates the active form, methylfolate, which is needed to methylate properly.

Now comes the refining stage, where your body takes the broken-down folate and other vitamin coenzymes and uses them in a special process called methylation. This is like the refinery turning crude oil into gasoline, diesel, and other products. In your body, methylation helps create important things like DNA and neurotransmitters (which help with mood and brain function).

Once your body has made what it needs, any extra folate or waste is cleared out, just like how a refinery manages its leftovers. This keeps everything in balance and running smoothly.

In the end, just as a refinery turns oil into fuel, your body turns folate into essential compounds that normalize your overall mental health and wellness.

Vitamin intake is not the problem, it's vitamin metabolism...how well we metabolize those vitamins to the active forms needed by the brain are what can put you at risk for various illnesses and now we have a way to circumvent all of those genetic variances

Andrew Farah, MD

Andrew Farah, MD , Chief of Psychiatry, High Point Division of UNC Healthcare

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The Vital Process called Methylation

Effectively managing depression and other psychiatric disorders requires an initial understanding of the intricate process of methylation—a vital cellular mechanism that occurs 24 hours a day in every cell of the body. This process is remarkably important for mental wellness, given its crucial role in neurotransmitter production, the chemicals that shape our mood.

 

The complex nature of methylation starts with the ingestion of vitamins and minerals through food. Subsequently, the body transforms these essential nutrients into an active and usable form to operate biochemistry through metabolism. This ongoing process repeats throughout our lifespan. While it typically operates smoothly for many individuals, some of us encounter difficulties in vitamin metabolism, potentially leading to symptoms related to depression, addiction, and mood disorders, while impacting overall mental wellness.  READ MORE

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The MTHFR Gene: Manufacturing Better Mental Health

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